Anti-NMDA receptor encephalitis is a neuroimmunologic disorder mediated by intrathecal autoantibodies against the GluN1 subunit of the NMDAr. It manifests with a range of neuropsychiatric symptoms, sometimes preceded by a viral-like prodromal syndrome. 1 The disorder frequently affects young adults, with a female predominance (4:1), though it.. NMDA receptor antibody encephalitis (NMDARE) is one of the most common autoimmune encephalitides, characterized by a recognizable constellation of neurologic and psychiatric features alongside positive NMDAR antibodies. 1,2 NMDARE mostly affects children and young adults, particularly females. It may be very severe in the acute phase with a mortality of about 5%, relapses occur in about 15% of.
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Autoimmune encephalitis (AE) is an important and treatable cause of acute encephalitis.. Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 2013;12:157-165. Crossref. PubMed. Google Scholar. 6.. Autoimmune encephalitis (AE) is an umbrella term for an emerging spectrum of immune-mediated neuropsychiatric disorders often associated with antibodies (abs) against neuronal cell surface, synaptic, or intracellular proteins. 1,2 Anti-NMDA receptor (NMDAR)-AE, anti-leucine-rich glioma-inactivated-1 (LGI1)-AE, anti-contactin-associated protein-like-2 (CASPR2)-AE, and anti-glutamic acid.
